Abstract: The current advancement, adoption, and access to technology in healthcare has emerged with increased benefits and some technological limitations and ac-acceptance. Introducing and integrating bioinformatics and cyber-physical systems in healthcare demonstrates increased technology-based healthcare. Its rapid evolution has brought forth a spectrum of privacy and ethical challenges to the health sector in general due to increased patient data breaches in digital healthcare systems like electronic health records and health management information systems. The study explicates the core concepts of bioinformatics and cyber-physical systems in healthcare. The study delves into the intricate landscape of privacy concerns, shedding light on managing sensitive healthcare data and the implications of regulatory frameworks. The study further highlights the real-world implications of these ethical and privacy, recommendations to mitigate these issues and heightened transparency, setting the stage for responsible innovation in the healthcare domain and future research directions.